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4F-MPH – A new synthetic amphetamine exhibits high potency and psychedelic boost

4-Fluoromethylphenidate has emerged as a novice synthetic drug of piperidine class which is a more powerful monoamine reuptake inhibitor. It also bears substitution in phenethylamine in its configuration.  Owing to its derivation from two classes as phenethylamine and piperidine, it produces prolonged euphoriant effects and acts like a major stimulant mimicking the action of monoamine neurotransmitter reuptake inhibitors. Ritalin or Focalin , chemically known as methylphenidate, is a structural counterpart of 4F-MPH. Ritalin is often given to treat ADHD.

It features a chemical formulation as C14H18FNO2 with a molar mass of about 251.3 g/mol.

4F-MPH structure feature high correspondence to amphetamines where piperidine ring bears a substitution at position R alpha terminating at phenethylamine. Methyl acetate is also attached at R2 in its configuration. Methylphenidate has similar molecular array but it lacks fluorination on phenethylamine at position 4. 4-MPH harbors phenyl ring linked via an ethyl group to an amino group, featuring a structural phenethylamine core.

By retaining dopamine and other monoamine neurotransmitters within the synaptic cleft owing to partial blockage of protein molecules responsible for reuptake of these neurotransmitters, it activates reward pathways which manifest as high motivation, euphoriant effects and stimulation.

Physically it is characterized via prominent effects as anorexia, tachycardia, dehydration, teeth grinding and physical stimulant effects. It has multitude of upshots incurred on cognitive abilities. These include enhanced focus, analysis boost, acceleration of thought, insomnia, high music discernment, euphoria, predominant emotional restraint, thought organization and cognitive fatigue.

4F-MPH has similar effects as methylphenidate with the former having more potent recreational tendencies. Anecdotally 4F-MPH is more powerful a stimulant with few side effects of compulsion of repeated intake, anxiety and muscular spasms. Few side effects associated with 4F-MPH are attributed to its high efficiency as a dopamine reuptake inhibitor.

Initially 4F-MPH was designed as an alternative to ethylphenidate which was banned on April 15th, 2015 in UK.

Toxicity profile of 4F-MPH is yet to be established for the drug is still a research chemical which has to be evaluated scientifically for its toxic dosage. Anecdotal reports from individuals reveal it to be devoid of any negative sequels as long as drug is consumed as low to moderate dosages. Nevertheless it has very insignificant history of human intake.

4F-MPH can lead to compulsive redosing as acute tolerance develops with extended usage of drug. However as it is devoid of substantial tolerant effect, it has great tendency to be abused like MDMA as well as amphetamines.

4F-MPH can lead to sudden comedown as after effects as soon as its peak levels fall for the dopamine receptors crave more levels as were synthetically created by the drug .These negative effects comprise of depression, fall in motivation, irritability, anxiety, insomnia , thought deceleration and cognitive fatigue.

4F-MPH is a controlled drug in Alabama, US while it is prohibited to manufacture, supply and import the substance in United Kingdom under Psychoactive Substance Act. Recently it is claimed to be a controlled drug in Canada on 5 May, 2017.