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5F-ADB, a new synthetic cannabinoid exhibits high potency

5F-ADB5F-ADB, which is known as 5F-MDMB-PINACA, is a synthetic cannabinoid in indazole-3-carboxaminde family and is one of many potent agonists of CB1 receptors. It is analogous with MDMB-CHMICA, cyclohexylmethyl indole. It is psychoactive, more strongly than other synthetic cannibinoids and has severe and adverse effects on human health.

The structure of 5F-ADB contributes to its chemical properties. It is based on scaffolding with indazole and indole and it features L-valinamide or L-tert-leucinamide side chains. 5F-ADB is very much related to 5F-ADB-PINACA, but the latter lacks a methyl ester group.

In accordance with IUPAC, 5F-ADB is formally named as methyl 2 – (1-(5-fluoropentyl) – 1H-indazole – 3 – carboxamido)-3, 3-dimethylbutanoate. It has a molar mass of 377.46 g/mol and its chemical formula is C20H28FN3O3.

5F-ADB is an active ingredient in products made from artificial cannibus. It is considered a designer drug. It is almost similar but chemically different from the natural tetrahydrocannabinol (THC). It is highly potent and can cause severe intoxication and, with associated semiconscious vomiting, death via asphyxiation.

While intoxicated, users show symptoms including psychomotor agitation, anxiety, confusion, and psychosis. In some instances users have reported believing they were possessed and had ‘super powers’. There is a high risk of over dosage, and exercising caution is extremely important. Only a small amount of smoke inhaled over a short period of time can be fatal.

In rats, it induced hypothermia (a potentially fatal condition of abnormally low body temperature) and bradychardia (a steady but slower than usual heartbeat, often less than 60 beats/min) at doses of 0.3—3.0 mg/kg, dose-dependently. In that study, hypothermia in rats was reversible with a pre-treatment of a CB1 antagonist (but was not reversibly with a similar pre-treatment with CB2).

This chemical compound was first identified in 2014 from a Japanese human cadaver.

As with other synthetic cannibinoids, there is a gap in the scientific literature regarding their chemical and pharmacological characterizations.

5F-ADB, in the United States, is classified as having a high potential for abuse and there is currently no accepted medicinal use for treatment or chemical therapy. It is considered a toxic and unsafe substance and is not even used under medical supervision. Prescriptions cannot be written for this substance in the USA.

Nevertheless, 5F-ADB has become prevalent as a recreational drug in both the United States and Europe.

5F-ADB can be extracted from human tissues through a modified QuEChERS method ( with filtration followed by liquid chromatography in tandem with mass spectrometry (LC-MS-MS) analysis. The ‘QuEChERS’ (Quick, Easy, Cheap, Effective, Rugged, Safe) method was originally designed as a simplified procedure to analyze various pesticide residues in grains, vegetables, and fruits and associated processed products.

It is banned in Japan due to mortalities caused by using products containing this chemical. It is classified as a Schedule 1 controlled substance in the United States.

See also
Cyclohexylmethyl indole
Designer drug