Buy fine quality research chemicals from Shanghai Chemical International Trade Co., Ltd

A-PPP crystal

appp crystalThough little studied, A-PPP crystal could be abused as a substitute for methamphetamine or cocaine.

A-PPP Crystal, a designer drug also known as α-pyrrolidinopropiophenone and sometimes called as α-PPP, alpha-ppp as well as (RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanone, weighs 203.28 g/mol and has the chemical formula C13H17NO. Structurally, it is close to pyrovalerone (its analog), diethylpropion (an appetite suppressant), and methcathinone. It is assumed to be less addictive and less potent than pyrovalerone or MDPV.

A-PPP crystal, a designer drug, produces effects similar to amphetamines in both humans and animals and can be used as a full substitution of methamphetamine, in terms of effects. Additionally, α-PHP, α-PPP, and ethylone could be used as a substitute for cocaine. Effects are also similar to A-PVP and A-PVT. Various users have made comparisons though a mixture of preferences has been reported in online forums. Specifically, these include euphoria, positive feelings, sexual arousal, talkativeness, rush, alertness, and a focused mind shortly (30 to 45 minutes) after ingestion and lasting up to three hours.

However, negative side effects include aggression, agitation, anxiety, blackouts, breathing difficulties, chest pain, combative behavior, confusion, disorientation, excited delirium, fatigue, hallucinations, hypertension, hyperthermia, increased suicidal ideations, insomnia, memory loss, mydriasis, myoclonus, palpitations, panic, paranoia, suppression of hunger, sweating, and tachycardia. The duration of negative side effects can last days.

In terms of potency, 3, 4-methylenedioxybutiophenone (MDPBP) is more potent than α-PPP, and α-PPP is in turn more potent than ethylone, which is more potent than α-pyrrolidinopentiothiophenone (α-PVT).

Sold as a solid crystal or white powder, it is soluble in organic solvents or aqueous buffers. Organic solvents must be removed through dilution with isotonic saline or aqueous buffers, since such solvents also have physiological effects. Note that α-PPP is a stimulant and an ingredient in ecstasy. Consumption may also be mediated nasally or through an IV needle.

When metabolized, the pyrrolidine ring is hydroxylated and then the corresponding lactam is dehydroxylated. Also, the aromatic ring is hydroxylated at position 4’ or dealkylation of the pyrrolidine ring to the corresponding parimary amine (cathinone) which is then followed by reduction of the keto group to the corresponding secondary alcohol (norephedrines).

In the UK, alpha-ppp is illegal because it is one of many substituted cathinones and is covered by the blanket ban of these substances. Because it is an analog of a controlled substance in New Zealand, Australia, and the United States, these countries may also consider it controlled as well. No country has licensed its use as medication or treatment for any purpose and it is not intended for animal or human use. It is sold exclusively as a research chemical.

To detect and prove the presence of A-PPP in a sample, rather than some other similar chemical that also metabolizes to cathinone and norephedrine, toxicologists must look for the unequivocal metabolite 2”-oxo-PPP. Toxicological detection can be performed on urine samples using GC-MS by looking for this combination of metabolites.

See Also:

1. 3,4-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP)
1. α-Pyrrolidinopentiothiophenone (α-PVT)
1. Alpha-Pyrrolidinopentiophenone (α-PVP)
1. α-Pyrrolidinohexiophenone (α-PHP)
1. 4′-Methoxy-α-pyrrolidinopropiophenone (MOPPP)
1. 4′-Methyl-α-pyrrolidinopropiophenone (MePPP)
1. 3′,4′-Methylenedioxy-α-pyrrolidinobutiophenone (MDPBP)