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acetylfentanylAcetylfentanyl is a powerful opioid analgesic and a member of the growing class of designer fentanyl analogues.

In terms of potency the following can be said about acetylfentanyl

  • It is 15 times less potent than fentanyl itself.
  • This still makes it 5 – 15 times more potent than heroin.
  • It is 80 times more potent than morphine.

It is important to note that one should not confuse potency with the quality of the experience provided by the drug. A higher potency than heroin just means that a smaller quantity will provide comparable pain relief and respiratory depression. Subjective reports tell us that fentanyl and its analogues do not produce a “high” as pleasurable as heroin. The euphoria or “high” is a separate characteristic of the drug completely separate from its potency.

In fact the extremely high potency of fentanyl and its analogues such as acetyl fentanyl would be considered by many to be a disadvantage of these drugs from a recreational drug use perspective. Fentanyl analogues have killed hundreds of people throughout Europe, especially in Eastern European countries that were once part of the Soviet Block. This is owing to a surge in the use of these analogues beginning in Estonia in the early 2000s. New fentanyl analogues continue to appear, and have recently become an issue in the USA.

In the States the DEA reports that between 2013 and 2015 there were 52 deaths directly linked to acetylfentanyl use.

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But what is it that makes acetylfentanyl and fentanyl analogues so dangerous?

Probably one reason is that unscrupulous drug users will mix acetylfentanyl in with heroin. Due to its high potency, this often results in an overdose.

Even when users are dealing with what they know to be relatively pure acetylfentanyl it still has a great potential to be a lethal drug. The high strength of the drug means it is difficult to dilute it properly. Highly accurate scales must be used, and then the quantity of powder should be fully dissolved and successively diluted a number of times before producing a sufficiently dilute solution that is considered safe to use. In fact, the powder is so high strength that accidently getting some of the solution on your skin can lead to an overdose.

Clearly people need to know what they are doing with this drug, and to treat it with the utmost care.

Fentanyl and its analogues cause greater respiratory depression relative to euphoria compared to other opiates. It is this suppression of breathing that results in loss of oxygen to the brain and ultimately death.

The subjective high produced by acetyl fentanyl is discussed online in unverifiable user reports.

Acetylfentanyl produces the usual experience associated with opiates. This includes physical and mental euphoria, pain relief, sedation and anxiety suppression.

The usual side effects are also present including itching, constipation, appetite suppression and decreased libido.

Unsurprisingly acetylfentanyl is highly addictive, and regular use will quickly result in physical dependence.