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Adinazolam: A derivative benzodiazepine

Adinazolam is a derivative benzodiazepine and especially a triazole benzodiazepine. Adinazolam has cramping, anxiety, antidepressant, and calming properties. Adinazolam was found by Dr. Jackson B. Hester, he was seeking to enhance the antidepressant properties of Alprazolam that he had also developed. Adinazolam has never been FDA approved and never placed on the market.

Molecular formula C19H18ClN5 and Molecular weight is 351.838 g/mol. Adinazolam is only found in individuals which have used or taken this drug. This drug has been produced and verified to meet ISO17025:2005 and Guide 34:2009 guidelines

Adinazolam is a Triazolobenzodiacepine with Anxiolytic and Antidepressive effect. Their effect is studied in various organic preparations and rat isolated differed and uterus conducts. When the medium of incubation contains: Cocaine, BETA, Estradiol, and Propranolol appear non-competitive antagonism. Adinazolam is a lack of Antimuscarinic and Antihistaminic effect H1. Adinazolam decreases the contracting effect induced by Ion potassium in preparations of deferred and uterine rat conduct, with inhibitor concentration-50 (IC50) of 3.51 X 10-5 and 1.48 x 10-4M respectively. In uterus isolated rate potency response to serotonin and composed as a non-competitive histamine antagonist on histaminoceptores H2.

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Adinazolam is the fastest elimination agent, but its concentration may remain high enough to achieve a sustained effect during the inter-dose interval. The active metabolite of adinazolam would be more potent but, because both the parent drug and the metabolite are rapidly eliminated, multiple doses would be required to maintain sustained plasma concentrations. For patients with frequent angst attacks, this drug provides minimal anxiolytic effects towards the end of the inter-dose interval. Fortunately, there are sustained release formulations which, by maintaining plasma concentrations within a range, allow a daily dosage of 2 times per day.

Alprazolam is the parent substance that has been chemically altered. The difference between these substances is that Adinazolam has got a dimethylamine group. And it was apparently tried to intensify the “anti-depressive” effect of Alprazolam.

Apparently, it is significantly weaker than the Alprazolam. Alprazolam is 10 times more potent than diazepam – i.e. 1.0 mg of Alprazolam corresponds to 10 mg of diazepam. Adinazolam, on the other hand, is indicated to be 3 – 5 less potent than diazepam, 30 to 50 times as weak as Alprazolam. The doses of Adinazolam are 30 mg and 50 mg. In the test series on abuse, Adinazolam was found to produce the largest “mental sedative/sedation” compared to diazepam (valium) and lorazepam (Ativan, Tavor), but it was also responsible for the greatest “unpleasant effect”.

Adinazolam 30 mg creates impairments for long-lasting on tests of attention, verbal and nonverbal and tracking information processing and memory. Visual information processing can be reduced with the 15 mg of Adinazolam. Supine mean arterial pressure also can be decreased by Adinazolam.

It is advisable to take Adinazolam under supervision or only after consulting the doctor as Adinazolam has many side effects if it has taken an overdose. There are many side effects that may occur such as ataxia, Dysarthria and particularly it is found in the children paradoxical excitement, muscle weakness. In more severe cases confusion, diminished reflexes and coma may arise.