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AlphamethylthiofentanylAlphamethylthiofentanyl or α-methyl-thiofentanyl is an opioid analgesic drug which is closely related to the medical painkiller fentanyl.

Alphamethylthiofentanyl is from a class of drugs called fentanyl analogues. They belong to the same class of drugs as heroin, morphine, oxycodon and of course fentanyl, and they share many of the same effects of these drugs. There is a wide range of fentanyl analogues.

This particular drug was briefly sold on the black market in the USA in the 1980s. It became illegal to possess or sell in the United States after the Federal Analogue Act. This was the first drug law which attempted to ban entire classes of drugs based on structural similarity, rather than scheduling drugs one by one.

Alphamethylthiofentanyl like fentanyl and its analogues is many times more powerful than heroin or morphine. Reports suggest however that it does not produce as intense a high as these drugs.

Fentanyl analogues are particularly dangerous for two reasons.

First is their extreme potency. A dose that looks like a couple of grains of salt could kill. The drug must be carefully prepared by dilution before using. An error in dilution can easily kill. They are used in the USA to cut pure quality heroin. Many deaths have resulted when gangs use too much of a fentanyl analogue to spike their product.

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The second thing that makes fentanyl analogues so dangerous is their ability to heavily suppress breathing. They suppress the respiratory system to a greater degree than other opioids relative to the euphoria produced.

Fentanyl and its analogues such as Alphamethylthiofentanyl are said to be more sedating in nature than other opioids. Pain relief is said to be significant, even at sub recreational doses.

The sensation of the “high” is described by unverifiable online reports. In physical terms it is usually described as strong feelings of bodily comfort, bliss and warmth. This is accompanied by a state of emotional bliss and contentment.

In case of overdose, the body’s nervous system is overpowered and the individual will lose consciousness. In this state breathing is impaired to such a degree that the bodily organs and the brain suffer from lack of oxygen and eventually the person dies. In other instances, individuals will die as a result of inhaling their own vomit.

Other common side effects of fentanyl analogues like Alphamethylthiofentanyl include difficulty urinating, loss of libido, constricted pupils, slurred speech, slowed coordination, sweating, itching and strong nightmares.

Alphamethylthiofentanyl is known to be highly addictive. Psychological and physical addiction rapidly develops with continued use.

Perhaps the most insidious aspect of these drugs is the physical addiction and dependence. This makes quitting very difficult.

Withdrawal effects set in hours after the last dose. They include but are not limited to fatigue, cramps, muscle pain, profuse sweating and cold sweats, restlessness, insomnia, fever, headache, anxiety and depression. There is also a strong craving for the drug which will end this painful process.

Relapse after coming clean is also very dangerous, as the individuals tolerance will have dropped significantly.