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Alprazolam

Alprazolam

Alprazolam for the symptomatic treatment

Alprazolam is a Triazolobenzodiazepine, a benzodiazepine with a Triazole ring. The chemical name is 8-chloro-1-methyl-6-phenyl-4H- [1,2,4] -Triazolo [4,3-α] [1,4] benzodiazepine.

Alprazolam is a white, crystalline powder. It is practically insoluble in water, but readily soluble in alcohol.

Alprazolam was developed by the company Pfizer, its patent protection ended in 1993.

Like all benzodiazepines, Alprazolam can lead to a psychological and physical dependence after a short period of ingestion. The risk of an addiction increases with the amount of dosage and the length of medication intake. Patients with known tablet dependence, drug or alcohol addiction in the pre history have an increased risk of addiction development. If a physical addiction develops, severe withdrawal symptoms such as pain, anxiety, hallucinations and epileptic seizures may occur when the medication is discontinued.

Alprazolam is soothing, relaxing and anxious. It is used for the symptomatic treatment of anxiety and panic disorders, as long as they are a severe burden on the patient. Alprazolam binds in the brain to benzodiazepine receptors, which in turn influence GABA receptors and increases the inhibitory effects of the neurotransmitter GABA.

View Also

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The duration of the application should be as short as possible. The total treatment time may be a maximum of 8-12 weeks. The dosage depends on the severity of the symptoms and the patient’s response. However, the daily dose of 3 mg should not be exceeded. If side effects occur, the dose should be reduced. In the indication of anxiety and panic disorders, daily doses of up to 12 mg have been shown to be therapeutically effective. When taking Alprazolam, the dose must be slowly reduced to avoid withdrawal symptoms.

Alprazolam should not be used for people who suffer from myasthenia gravis, severe disturbance of the liver or lung function, or sleep apnea. Alprazolam is not suitable for the sole treatment of psychoses.

Since Alprazolam is metabolized in the liver, inter alia by the Cytochrome P450, it can lead to manifold interactions with other medicines. In particular, concomitant treatment with Antimycotics such as Ketoconazole or Itraconazole is not recommended.

Other drugs active in the brain, such as Neuroleptics, Antihistamines, and Antidepressants, can be intensified in their effect, or in turn enhance the effect of Alprazolam. Alcohol also enhances the effect of Alprazolam. This has effects on the ability to drive.

There is insufficient data on the safety of the fetus for use during pregnancy. However, Alprazolam can enter the child’s blood circulation through the placenta. Furthermore, there are indications of possible damage to unborn life, especially in the last trimester of pregnancy. The medicine should, therefore, be used only under strict indications.

During breastfeeding, Alprazolam should not be used as it passes through the mother’s milk to the infant as it can cause severe side effects and physical dependence. Alprazolam affects alertness and can lead to side effects such as somnolence, decreased responsiveness, delusions and muted emotions. Anterograde amnesia may also occur. In patients with depression, the depressive symptoms can be strengthened. Especially in elderly patients, there may be so-called paradoxical reactions by Alprazolam – if restlessness, confusion, agitation or other psychological behavior disorders occur, the drug must be discontinued.