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eg-018EG-018 is a synthetic cannabinoid and analogue of the naphthoylindole cannabinoid JWH 018.

EG-018 is reported to have cannabinoid effects similar to JWH-018, however it remains untested as to its specific pharmacological potency.

EG-018 bears the formal and systematic IUPAC name naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone. It is a white crystalline solid at room temperature pressure with a melting point of 97.5 oC. EG-018 has a molar mass of 391.5 grams and empirical formula C28H25NO.

Structurally EG-018 consists of a naphthoyl moiety bound to aminoalkylindole by a ketone containing bridge. A hydrophilic side chain is attached to a nitrogen enhancing the lipophilicity of the molecule.

It most likely is a potent full agonist at CB1. This is inferred from the structure of EG-018 which bears a similarity to other synthetic cannabinoids like JW-018, and on the effects that EG-018 are reported to produce.

The CB1 receptor is the site of action of THC, the primary psychoactive constituent of herbal cannabis (marijuana). THC acts as a partial agonist at this receptor. Due to the potency and full agonist action of the synthetic cannabinoids, they produce a range of effects comparable to, but much stronger than THC. They also can be lethal if taken in overdose, unlike marijuana. This is a consequence of their full agonist action.

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Typical effects of CB1 agonists include decrease or increase in anxiety, pain relief, increased appetite, slight loss of control of body coordination and lowering of blood pressure.

EG-018 is a highly novel drug compound. The effects of short term or long term recreational use of EG-018 on health are not known. EG-018 is not for human or animal consumption.

Unverifiable online reports give us some insight in to the effects of EG-018.

Reports claim it is a highly sedating compound with doses reported in the same range as JWH-018.

EG-018 is reported to produce a strong “body high” which has been described as a sensation of tingling which emerges and spreads over the entire body. Users report a soft and warm feeling that increases from the point of onset to the peak of the “high” before dissipating once more. It has been described by some as more “synthetic in feel” and not as pleasant as the body high produced by traditional herbal cannabis. At higher doses some users report that the feeling is in fact quite uncomfortable and may induce anxiety.

Other physical effects of EG-018 which have been reported include pain relief, dehydration and changes in the perception of gravity.

Cognitive effects of EG-018 may include states of euphoria. Generally however, cannabinoids are reported as enhancing whatever emotional state the user is in, which may lead to increasing fear or anxiety or uncontrollable laughter.

Therefore a range of emotional experiences are possible. There are reports of users feeling anxious under the influence of EG-018. Other cognitive effects produced include feelings of depersonalisation, derealisation, and suppression of short term memory, states of heightened paranoia, dulled or slower thinking.

Cannabinoids may induce states of psychosis or exacerbate latent mental illness especially in young adults and adolescents.