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Ephylone / bk-ebdp

bk-ebdpEphylone otherwise known as bk-ebdp) is a substituted cathinone . It is comparatively new and as such there is little data available on it. It is the N-methyl analogue of the cathinone pentylone.

Ephylone / bk-ebdp has the formal systematic IUPAC name (benzo[d][1,3]dioxo1-5-y1)-2-(ethylamino)pentan-1-one, an empirical molecular formula of C14H19NO3, and molar mass of 250g.

Substituted cathinones otherwise known as β-keto amphetamines such as Ephylone / bk-ebdp are psychoactive stimulatory chemicals distinguished by having a phenethylamine backbone with various alkyl substituents at the alpha position adjacent to the nitrogen and a ketone at the beta carbon. They all are related to cathinone, a naturally occurring chemical found in the plant Khat (Catha edulis) native to the horn of Africa. Khat is chewed to release the cathinone which is described as an amphetamine like substance that caused feelings of energy and excitement, euphoria and a marked reduction in appetite.

One of the most famous derivatives of cathinone which was highly popular at the end of the last decade is mephedrone otherwise known as 4-MMC. It produced feelings of euphoria similar to MDMA and cocaine.

Pentylone is another member of this class. It acts as a serotonin-norepinepherine-dopamine reuptake inhibitor and to a lesser extent acted to release serotonin. All of the typical cathinones are potent norephedrine reuptake inhibitors. Individuals within the class differ in their dopamine versus serotonin transport inhibition with some more inclined to dopamine reuptake inhibition and others stronger serotonin reuptake inhibitors.

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Additionally there is differences in the degrees in which different members of the cathinone family of chemicals will cause a release of mono-amines in to the synaptic cleft.  For instance mephedrone is a more potent serotonin than dopamine reuptake inhibitor and releases norepinepherine and serotonin in a similar manner to MDMA. Pentylone and 4-MEC by contrast inhibits reuptake of all three of the monoamines equally and releases serotonin.

By crude analysis of the structure of Ephylone / bk-ebdp it may perhaps have a drug profile more closely aligned to pentylone than to mephedrone.

Ephylone / bk-ebdp differs from the chemical pentylone by having the nitrogen in the secondary amide substituted with an ethyl group instead of a methyl group.

Pentylone which is a closely related compound has been described in online reports as having euphoric, entactogenic, sedating, calming and paradoxically stimulatory effects. It is of interest to see how the substitution of a methyl for an ethyl in pentylone might affect binding at the various monoamine reuptake binding sites and in release of the monamines. Often a small change such as this can produce marked differences in binding and subjective effects.

Toxicological, pharmacological and physiological data for Ephylone (bk ebdp) in humans or animals does not exist. It is therefore not fit for consumption in animals or humans.

There are few verifiable online reports of use of Ephylone / bk-ebdp with some users reporting a mild stimulatory effect.  Online reports also suggest use of caution as some of these cathinones are reported to be habit forming.