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Ethyl hexedrone

hexenEthyl hexedrone is yet another member of the large family of compounds known as substituted cathinones. It goes by alternative names “hexen” and “n-ethyl-hexedrone”.

The structural signature of the substituted cathinone class of compounds is a phenethylamine backbone with an alkyl group of various lengths at the alpha carbon adjacent to the nitrogen and a ketone in the beta position. The cathinones are a beta-keto analogue of amphetamines.

It is hypothesised that ethyl hexedrone is a noradrenaline-dopamine reuptake inhinitor like the cathinones MDVP and alpha PVP. There are no scientific studies confirming its status as a noradrenaline dopamine ruptake inhibitor.

Ethyl hexedrone is a structural analogue of the substituted cathinone hexedrone. The substitution of the nitrogen with an ethyl group increases the potency of ethyl hexedrone by a factor of three compared to its chemical relation hexedrone.

It was first synthesised in the 1960s by Boerhringer Ingelheim, but only became widely known as a “research chemical” as of 2015. It is suffice to say then that little information exists on this compound with such a short history of human use.

Ethyl hexedrone has the formal and systematic IUPAC name 2-(Ethylamino)-1-phenylhexan-1-one. It has a relative molar mass of 219.33 grams and an empirical formula of C14H21NO.

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It is possible to compare ethyl hexedrone to the much more widely known cathinone pentedrone. Ethyl Hexedrone features an extension of the carbon chain extending from the aryl group by one carbon. In the structure activity of this class lengthening of the alkyl chain from 5 to 6 generally causes a diminishment in potency. However the substitution of an ethyl group at the amine increases potency.

As stated there are no formal studies on the pharmacological action on ethyl hexedrone. A hypothetical conjecture is that ethyl-hexedrone acts as an NDRI (noradrenaline-dopamine reuptake inhibitor) purely based off its structural similarity to pentedrone and MDPV.

NDRIs block the reuptake of dopamine and noradrenaline released in to the synaptic cleft. These neurotransmitters subsequently spend a longer time at the receptor increasing their effect. Dopamine in particular is a potent endogenous reward chemical released after exercise and sex. This gives potent NDRIs strong stimulatory effects and potential for inducing states of euphoria.

Ethyl hexedrone is not fit for animal or human consumption.

Purely subjective an unverifiable online reports claim that this compound has a stimulatory profile of effects. Physical effects of ethyl hexedrone which have been reported include pleasureable body tingling sensations, increased energy levels, dry mouth, sweating, dehydration, vasoconstriction, enhancement of touch, elevated heart rate, decreased appetite, increased focus, difficulty maintaining erection, increased blood pressure and teeth grinding comparable to MDMA.

Cognitive effects which have been reported online include feelings of euphoria, increased motivation, increased appreciation of music, greater immersion in activities, acceleration of thought processes, increased analytic abilities at low doses and inflation of the ego.

It has been reported as generating a compulsion to redose.

Negative after effects have been reported and these include difficulty sleeping, loss of motivation, irritability, depressed mental states, difficulty thinking and anxiety.

All stimulants have an ability to induce psychosis if used over protracted periods of time or at high doses.