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flobromazepamFlubromazepam is a long-lasting benzodiazepine designer drug

Flubromazepam first appeared in 2012 as a new benzodiazepine designer drug analogous to phenazepam except for a fluorine atom substituting for a chlorine atom. Its structure contains a benzene ring and a diazepine ring. It was artificially created much earlier, in 1960 as a ‘research chemical’ since it was not marketed. Henryk Leo Sternbach and Earl Reeder patented it in the United States while they worked at the pharmaceutical company Hoffman La Roche.

Flubromazepam is not medically approved in any country and is solely used recreationally. There might be some potential utility for sedation in hospitals, short-term treatments for acute seizures or as an anti-anxiety. Note that sudden withdrawal after regular usage may cause seizures or death, and tapering off is highly recommended.  

Potentially, the name ‘flubromazepam’ also refers to an isomer: 5-(2-bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one.

Formally, the IUPAC name is 7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one. Its molar mass is 333.16 g mol-1 and it has a chemical formula: C15H10BrFN2O.

The biological half-life is roughly four days and ten hours and until recently it was thought to be difficult to detect in urine samples. More recently, immunoassays such as CEDIA and KIMS II have been used to identify and confirm detection in blank urine spiked with the drug and authentically intoxicated urine samples. In blood, it can be detected using a Immunalysis Benzodiazepine ELISA kit and has detected concentrations in blood as low as 0.0047 mg L-1.

Firsthand accounts report at least an hour before full effects are felt yet redosing increases the risk of overdosing. Long elimination half-life could result in accumulating concentrations that are injurious or fatal, particularly when interacting with depressants including methadone, heroine, or alcohol. Metabolites include a monohydroxylated compound and a debrominated compound.

Physical effects include anxiolytic effects, muscle relaxation, fatigue, amnesia, sedation and sleepiness. Because of its low detectability, flubromazepam might be attractive to individuals undergoing drug withdrawal or when undergoing regular testing for drugs.

See Also:

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  • 2-Oxoquazepam
  • Camazepam
  • Bromazepam
  • Chlordiazepoxide
  • Cinazepam
  • Cyprazepam
  • Clorazepate
  • Delorazepam
  • Carburazepam
  • Demoxepam
  • Flubromazolan
  • Diazepam
  • Flurazepam
  • Diclazepam
  • Ethyl dirazepate
  • Ethyl carfluzepate
  • Fludiazepam
  • Elfazepam
  • Desmethylflunitrazepam
  • Ethyl loflazepate
  • Gidazepam
  • Fletazepam
  • Iclazepam
  • Flunitrazepam
  • Halazepam
  • Flutemazepam
  • Irazepine
  • Flutoprazepam
  • Kenazepine
  • Fosazepam
  • Ketazolam
  • Meclonazepam
  • Lorazepam
  • Medazepam
  • Lormetazepam
  • Metaclazepam
  • Lufuradom
  • Menitrazepam
  • N-Desalkylflurazepam
  • Motrazepam
  • Nifoxipam
  • Oxazepam
  • Nimetazepam
  • Phenazepam
  • Nitrazepam
  • Pinazepam
  • Nitrazepate
  • Pivoxazepam
  • Nordazepam
  • Prazepam
  • Nortetrazepam
  • Proflazepam
  • Reclazepam
  • Quazepam
  • Ro5-4864
  • QH-II-66
  • RO4491533
  • Sulazepam
  • Tetrazepam
  • Uldazepam
  • Temazepam
  • Doxefazepam
  • Tifluadom
  • Devazepide
  • Tolufazepam
  • Clonazepam
  • Triflunordazepam
  • Cinolazepam
  • Tuclazepam