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FUB AKB48

fub-akb48FUB AKB48 goes under the formal and systematic IUPAC name N-(adamantan-1-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide, has a molar mass of 403.5 grams and has the empirical chemical formula C25H26FN3O.

FUB-AKB48, which also goes by the name FUB-APINACA, is a member of the emergent class of indazole synthetic cannabinoids that have come to the attention of scientific forensic laboratories around the world in the last two years.

The past decade has seen a plethora of novel synthetic cannabinoids have emerged, with the indazole and indole class being some of the latest and most powerful. They may be consumed by users by an oral or inhalation route and are seen by some as an alternative to herbal marijuana and as a means to get “high”.

Detailed pharmacological, physiological and toxicological data for these new chemicals is often lacking. Therefore they are not fit for human or animal consumption.
Like other indole and indazole based cannabinoids FUB AKB48 is a potent and full agonist at the human cannabinoid receptor CB1.

FUB AKB48 is structurally related to the indazole cannabinoids APINICA and 5F APINACA. It diverges from these molecules with respect to the lipophilic pentyl side chain attached to the indazole nitrogen which has been replaced by a flourobenzyl moiety attached to the nitrogen via a rotatable methyl bridge to give the new compound FUB-AKB48. All these compounds belong to an adamantly sub class of the indazole cannabinoids.

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Flourination of the pentyl side chain in APINICA to produce 5F APINACA greatly enhanced binding affinity due to increased electronegativity. Addition of fluorine to the benzene ring in FUB-AKB48 in all likelyhood has a similar effect on potency. Intrinsic or endogenous molecules in the central nervous system do not include floruine atoms and are limited generally to carbon, nitrogen and oxygen. Halogenation of drug molecules in selected parts of the chemical will produce binding interactions that exceed that of the binding of the endogenous chemical. This often produces extremely high affinities and long duration of action.

As a result these new fluorinated synthetic cannabinoids produce a profile of effects that far exceeds that of delta 9 THC in both strength and duration also with the risk of overdose, hospitalisation and death unlike herbal marijuana. FUB-AKB48 has extremely high potency like other members of its class. It acts as a full agonist at human cannabinoid receptor CB1 with a binding affinity of 1.06 nM and at CB2 with a binding affinity of 0.174 nM.

FUB-AKB48 is not fit for human consumption.

Speculative and unverifiable online reports suggest an extremely potent sedating and marijuana type high from ingestion of FUB AKB48. Doses may be extremely low. Even experienced “users” should thoroughly investigate dose ranges starting from the lowest. Measurement of doses is typically with a mg active scale and often using volumetric titration techniques. Online reports strongly encourage ingestion by a cold process. Heating of the fluorinated molecule may have deleterious effects on human health.

Cold ingestion processes include oral, rectal, transdermal and ultrasonic nebulisation. Delivery methods to be avoided include smoking, thermal vaporisation (which includes pipes, virtually all e-cigaretes) or hot irons. Heat may cause thermal degradation of the compounds leading to ingestion of toxic fluorinated by-products. As with all novel synthetic cannabinoids online reports emphasise extreme caution with respect to dose as overdose may result in seizure, hospitalisation or death.