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methoxy-Acetylfentanyl is a fentanyl analog designer drug

methoxy-Acetylfentanyl (also written as Acetyl fentanyl or more formally as N-(1-Phenethylpiperidin-4-yl)-N-phenylacetamide) is an opioid analgesic designer drug analog of fentanyl in the piperidine class of chemicals. Acetylfentanyl is roughly 15 times more potent than heroine and up to 80 times more potent than morphine but 15 times less potent than fentanyl.

Recreationally, it may serve as a heroin or other opioid substitute. In some cases it has been sold as ‘China White’ though this name could refer to any of at least four different chemical substances.

The structure of acetylfentanyl contains a piperidine ring that binds at RN via an ethyl chain to a phenyl ring. Opposite to the piperidine ring, the carbon binds to the acetamide group’s nitrogen. The acetamide is two carbons with a nitrogen group adjacent to a carbon bonded to a ketone oxygen. The additional phenyl ring is substituted at RN.methoxy-Acetylfentanyl  has one less carbon on its amide compared to fentanyl.

methoxy-Acetylfentanyl is short-acting and highly addictive as a μ-opioid receptor agonist. This makes it a recreational drug because opioids are structurally similar to natural endorphins, resulting in physical euphoria, dream potentiation, sedation, cough suppression, anti-anxiety effects and pain relief.  Endorphins reduce pain, cause pleasurable feelings, and cause drowsiness, and are released to counteract pain or to respond to difficult exercise, orgasm or excitement.

Side effects of acetylfentanyl include nausea, constricted pupils, suppression of appetite, suppression of orgasms, decreased libido, constipation, difficulty urinating, itchiness, compulsive redosing, and potentially fatal respiratory depression (hyperventilating).

As with many other designer drugs, interactions with depressants, stimulants, and dissociatives can be dangerous and induce mortality.

methoxy-Acetylfentanyl can be quantified in urine, blood, or plasma by liquid chromatography-mass spectrometry for diagnosis or postmortem confirmation.


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