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Mexedrone Crystal

mexedronemexedrone, a new synthetic cathinone exhibits high potency

Mexedrone is the member of cathinone family where other family members are mephedrone, MDPV and methylone. Cathinone are characterized by a core of phenetylamine bonded with alkyl group with a ketone group structurally linked to the molecular configuration. Mexedrone is found to be highly interactive with synapses owing to its configuration. Cathinones have emerged as potent modifiers of reuptake of synaptic neurotransmitters radically for serotonin, norepinephrine and dopamine. This action enhances concentration and bestows euphoria.

Mexedrone has the chemical formula as 3-methoxy-2-methylamin-1-p-tolyl propan-one with a molecular weight of around 207.27gmol-.

Being a synthetic analogue of cathinones, it bears structural homology with amphetamines with cathinone having an addition of ketone group at position R1 while both are alpha methylated forms of phenethylamines.

Mexedrone further harbors an accessory alteration at RN apart from R4 within its core phenyl ring. Mexedrone has been claimed as structurally kindred to mephedrone with latter deprived of the accessory methoxy group.

This molecule functions as inhibitor of reuptake as well as a releasing agent for neurotransmitters as dopamine, noradrenaline and serotonin. Various case reports have revealed the fact the mexedrone acts more as a sedative than a stimulant for the reason it may be responsible for secretion of less dopamine than serotonin mimicking action of MDAI.

Although mexedrone has great affinity for dopaminergic system yet it has merged as less neurotoxic over its other relatives like methamphetamine. This is attributable to its hydrophilic nature which obscures its entrance in to the brain cells.

Mexedrone physically manifests as tactile stimulation, physical sensations, euphoria, sedative effects, nystagmus ( vibratory movements of eyeballs), dehydration, grinding of teeth, enhanced perspiration and suppression of temperature regulation.

Mexedrone also has profound impact on cognition as thought rapidity, high connectivity of thoughts and emotional euphoria together with contentment. It also promotes auditory enhancements.

Following the peak levels of mexedrone, it behaves like a craving stimulant, wanting high levels to maintain the so produced levels of monoamine neurotransmitters. With the offset of mexedrone, a comedown state incurs with negative effects as irritability, anxiety, depression, insomnia, lack of motivation, cognitive fatiguability and deceleration of thought process.

If used in combination with drugs like MAOI s including Syrian rue and antidepressants, SSRIs and hydroxytryptamines, it can insue in serotonin syndrome.

It usually is taken as insufflations while many drugs amongst cathinones are orally ingested. Mexedrone can also be given as an injectable substance for it is soluble in water.

Mexedrone has occupied a grey zone in terms of legality all across the globe. The substance has high accessibility from online vendors in the form of research substance. Its pivotal demand in research has not however given its immunity against legal ban.

Under the influence of Psychoactive Substance Act, 26th May 2016, mexedrone was labeled to be illegal. This substance has also been banned from pharmacies in Sweden and Japan.