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Ohmefentanyl

OhmefentanylOhmefentanyl goes by a number of alternative names including RTI-4614-4, OMF and hydroxy-3-methylfentanyl. It is an extremely potent opioid analgesic drug that binds selectively to the µ-opioid receptor. It is also an analogue drug of fentanyl, the powerful medical painkiller. Analogue drugs are those with a similar backbone structure, with some small alteration. They often have effects similar to the parent compound, but differ in strength and perhaps have some additional qualities of their own or a loss of some of the qualities of the parent drug. They vary in usefulness and toxicity in comparison to the more commonly used and usually older parent drug compound.

Drugs like Ohmefentanyl that bind to the µ-opioid receptor are used as substitutes for heroin, oxycodon and morphine by addicts as they produce largely the same effects. Fentanyl and its analogues have been widely abused because of this. It is important to note however that they are many times more powerful than heroin, and a tiny amount can incapacitate or kill.

Ohmefentanyl is in fact one of the most potent μ-opioid receptor agonists ever made. It is comparable to drugs like etrophine and carfentanil which are used as tranquilizing agents for large animals like elephants and even as chemical weapons.

One isomer of Ohmefentanyl was found to be:

  • 28 times more powerful than fentanyl.
  • 6300 times more powerful than morphine.

There are 8 different stereoisomers of Ohmefentanyl.  Sterioisomers are  compounds with the same atoms bonded in the same order, but they differ in the way these atoms are arranged in three dimensional space. This is analogous to your left and right hand. They both have the same number of finger and thumbs, but are arranged in a different way such that they fit different gloves. This analogy can be taken further if the glove is compared to the drug receptor. Some stereoisomers fit the µ-opioid receptor better than others. Thus scientists have labelled these versions of Ohmefentanyl F9201–F9208. They are still discerning the individual properties of each through continued research.

See Also

By adding a fluorine atom to one isomer of ohmefentanyl scientists created an opioid drug with an astonishing potency 18,000 times greater than that of morphine.

Another analogue where a carboethoxy group is added to the fourth position of the piperidine ring on ohmefentanyl has potency 30, 000 times greater than morphine.

The side effects of ohmefentanyl are similar to fentanyl itself. The most dangerous side effect of these drugs is they cause high levels of respiratory depression relative to the euphoric “high” they produce. This in combination with their unwieldy and dangerous potency means that fentanyl analogues have killed many thousands of people due to drug overdoses.

The fentanyl analogues are also highly addictive. They cause physical dependency, and are associated with a tough withdrawal period after cessation of use.

Symptoms of withdrawal from fentanyl and fentanyl analogues include cramps, muscle pains, fever headache, sweats, fatigue, nausea and vomiting, depression, insomnia, anxiety and drug cravings.