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th-pvpTH-PVP – A new synthetic cathinone exhibits high potency and psychedelic boosts

TH-PVP dubbed as flakka is an exuberant stimulant of brain activity that boosts psychological functional capacity as well as central nervous system. Belonging to cathinone class ,it acts as a dopamine and norepinephrine reuptake inhibitor where it enhances the concentration of neurotransmitters like dopamine and norepinephrine, thereby giving mood boosts and central nervous stimulant effects.

It has an IUPAC name as 2-(pyrrolidin-1-yl)-1-(5, 6, 7, 8-tetrahydronaphthalen-2-yl) pentan-1-one with a molecular formulation as C19H27NO. It possesses a molecular weight of about 285.42g. Owing to its psychedelic properties it is renowned as a recreational drug. This synthetic compound has a quarter of the total potency of MDPV where its psychoactive and neural effects correspond with MDPV. It belongs to the NDRI class.

TH-PVP also named as pyrrolidinopentiophenone, belonging to ketone as well as pyrrolidine chemical groups, has emerged a potent alkaloid. It is not only an effective booster of central and cognitive nervous functions but also a strong stimulant of cardiovascular physiology. Its structure features a pentanal group attached to a phenyl ring and bound to nitrogen of pyrrolidine group.

Flakka has some stimulatory properties and is mildly hallucinogenic when given in low dosages. It brings about the release of euphoric brain substances as monoamine neurotransmitters like dopamine and norepinephrine. Furthermore it also blocks the absorptive processes in neuronal cells responsible for reuptake of these neurotransmitters. Therefore the stimulatory effects keep straggling within nervous system for a period greater than that anticipated.

TH-PVP has emerged as more powerful drug than 4F-PVP, A-PBP and its configuring analog A-PVP. The mental manifestation in the form of ‘rush’ is achieved within a minute when given intranasally. It gives the user a stunned feeling and imparts a state of well being, enhanced ego, paranoia, hyperactivity and mesmerizing euphoric state.

TH-PVP is entirely divergent in its redosing and dependence effects from the rc classified substances as it has obtained a longer duration of function. Psychological dependency effects and physiological symptoms typical of withdrawal are less likely to be associated with TH-PVP. However some anecdotal studies particularly in pre research trials gave an association of debilitating headaches with use of the substance. This headache effect was attributed to the slowness of effect being produced by the drug.

TH-PVP dosing used in the pre research trials was found to be 10mg at first which then was identified to be at least 20mg as a threshold level for better effectiveness.

TH-PVP is not banned in majority of the countries yet it can be considered as an illegal drug in regards to Synthetic Drug Abuse Prevention Act passed in United States under 1152 SEC which encompasses addition of schedule I to synthetic drugs as illegal. If research proves and lists TH-PVP as a schedule I drug, it would be banned immediately. Owing to paucity of research studies on the drug this drug is not available for medical and human usage for the fear of an associated drug abuse. Nevertheless the drug is given great protocol to in scientific research laboratories and forensics till the drug’s medical benefits unveil and classify it as human drug especially when in toxic profile is formulated including addictive and abuse potential.