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thj-2201THJ-2201 is a synthetic cannabinoid of the indazole class. It is an analogue of AM-2201.

It acts as a full agonist at CB1 and CB2. It binds strongly to the human cannabinoid receptors with a binding affinity of 1.34 nM at CB1 and 1.32 nM at CB2.

The chemical structure of THJ-2201 centres on the indazole ring structure at the heart of the molecule. This indazole is substituted at R1 with a fluoropentyl chain, a substitution that is found in many other cannabinoids including 5F-AKB48 and 5F-PB-22.

In addition to this the indazole core is further substituted at the R3 carbon with a naphthalene group via a methyl ketone bridge.

THJ-2201 has been linked to at least one fatality.

The health effects of long term or even short term recreational use of THJ-2201 are not known.

The fluorinated synthetic cannabinoids such as THJ-2201 are speculated to pose an additional risk to respiratory health.

They tend to have high boiling points in excess of 500 OC. On heating, a proportion of the drug crystal is likely to undergo combustion before vaporisation.

This will produce reactive and toxic fluorocarbon degradation compounds which would have a noxious effect on the respiratory mucosal membrane.

These compounds therefore, pose a hazard to health if consumed by a hot method, and it would not be unsurprising if they contributed significantly to respiratory illness in users.

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If an individual is intent on us it is recommended to consume them by a cold method. This would include simple oral ingestion, or vaporisation via a cold method such as sonic vaporisation. Note that the vast majority of “E-Cigarette” vaporisers on the market produce vapour by a thermal method.

THJ-2201 is not fit for human or animal consumption.

Unverifiable online reports give use some indication as to the effects of this compound.

It is said to produce a strong stoning effect and a “body high” which has been reported as a tingling sensation that envelops the whole body and which is variously described as pleasurable or uncomfortable. This body sensation is said to increase in intensity from the onset of the experience, reaching a peak and then dissipating after the “high”.

THJ-2201 is reported as being heavily sedating and may cause individuals to fall asleep.

Additional physical effects which have been reported include abnormal heartbeat, tachycardia, dehydration and dry mouth, nausea, vomiting, changes in perception of gravity, feelings of vertigo, pain relief, loss of motor control and increased appetite.

THJ-2201 is reported as enhancing the current emotional state of the user. This can produce emotions that range from euphoria and uncontrollable laughter to anxiety, paranoia and depersonalisation. THJ-2201 is reported as reported as suppressing short term memory and interfering with cognitive function.

Some users have reported an increased appreciation of music.

Prolonged use of cannabinoids may increase an individual’s likelihood of developing an illness such as anxiety, depression and even schizophrenia. This is particularly the case in young adults and adolescents.

THJ-2201 is considered to be addictive, with a high potential for abuse. It may produce psychological dependence in some and withdrawal effects have been reported post cessation.